管放 直聘副研究员
● 工作经历
2025.1-至今 郑州大学 直聘副研究员（硕导）
2021.1-2024.12 南京农业大学 钟山青年研究员
● 研究兴趣、领域：
主要从事昆虫寄主适应性及杀虫剂毒理学方面的研究。
● 主持或参加的项目：
1. 国家自然科学基金青年项目，2026–2028，30万元，主持；
2. 河南省自然科学基金青年项目，2026–2027，5万元，主持；
3. 郑州大学专职科研岗启动基金项目，2025–2026，20万元，主持；
4. 江苏省自然科学青年基金项目，2023–2026，20万元，主持；
5. 国家重点研发计划项目，2022–2025，1987万元，参加；
6. 新疆农业科学院稳定支持专项，2022–2023，6万元，参加；
7. 国家自然科学基金重点项目，2020–2024，276万元，在研，参加；
8. 国家自然科学基金重点项目，2016–2020，274万元，结题，参加。
● 代表性论著：
1. Fang B., Shi Y., Mei W., Yang Y., Guan F.* and Wu Y*. 2026. Widespread high-level resistance to emamectin benzoate and chlorantraniliprole and associated resistance mutations in Spodoptera exigua across China. Pest Management Science. 82: 5163–5172.
2. Guan F., Fang B., Mei W., Zeng S., Yang Y., Oakeshott J.G., and Wu Y*. 2026. Ongoing insecticide resistance evolution in beet armyworm via changes in the utilization of pre-existing and new mutations. Pesticide Biochemistry and Physiology. 218: 106929.
3. Shen H., He Y., Yang Y., Guan F., Carriere Yves and Wu Y*. 2026. Synergistic epistasis confers strong and dominant resistance to Bacillus thuringiensis toxin Cry1Ac in Helicoverpa armigera. Pesticide Biochemistry and Physiology. 216: 106812.
4. Guan F., Xiao X., Dong R., et al. 2025. Detection and functional validation of point mutations in acetylcholinesterase-1 associated with organophosphate resistance in field populations of Helicoverpa armigera. Journal of Economic Entomology. 118(1): 359–368.
5. Wang C., Zhang Y., Sun Q., Li L., Guan F., et al. 2025. Species-specific evolution of lepidopteran TspC5 tetraspanins associated with dominant resistance to Bacillus thuringiensis toxin Cry1Ac. Journal of Integrative Agriculture. 24(8): 3127–3140.
6. Wang C., Zhang Y., Guan F., et al. 2025. Genome-wide identification and phylogenetic analysis of the tetraspanin gene family in lepidopteran insects and expression profiling analysis in Helicoverpa armigera. Insect Science. 32(2): 471–486.
7. Guan F., Dai X., Hou B., et al. 2023. Refuges of conventional host plants counter dominant resistance of cotton bollworm to transgenic Bt cotton. iScience. 26(5), 106768.
8. Guan F., Zhang Z., Lin Y. et al. 2023. Susceptibility and diagnostic concentration for Bacillus thuringiensis toxins and newer chemical insecticides in Spodoptera frugiperda (Lepidoptera: Noctuidae) from China. Journal of Economic Entomology. 116(5), 1830–1837.
9. Guan F., Dai X., Yang Y., et al. 2023. Population genomics of nonrecessive resistance to Bt toxin Cry1Ac in Helicoverpa armigera from northern China. Journal of Economic Entomology. 116(2), 310–320.
10. Zhang J., Zhang F., Tay W.T., Robin C., Shi Y., Guan F., et al. 2022. Population genomics provides insights into lineage divergence and local adaptation within the cotton bollworm. Molecular Ecology Resources. 22(5), 1875–1891.
11. Guan F., Hou B., Dai X., et al. 2021. Evolutionary origin of a single point mutation in the cotton bollworm tetraspanin gene confers dominant resistance to Bt cotton. Pest Management Science. 77(3), 1169–1177.
12. Guan F., Zhang J., Shen H., et al. 2021. Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda. Insect Science. 28(3), 627–638.
13. Wei Y., Guan F., Wang R., et al. 2021. Amplicon sequencing detects mutations associated with pyrethroid resistance in Bemisia tabaci (Hemiptera: Aleyrodidae). Pest Management Science. 77(6), 2914–2923.
14. Zuo Y., Shi Y., Zhang F., Guan F., et al. 2021. Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm. PLoS Genetics. 17(7), e1009680.
15. Jin L., Wang J., Guan F., et al. 2018. Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bollworm to transgenic Bt cotton. Proc. Natl. Acad. Sci. U.S.A. 115(46), 11760–11765.
16. Che W., Wang J., Guan F., et al., 2015. Cross-resistance and inheritance of resistance to emamectin benzoate in Spodoptera exigua (Lepidoptera: Noctuidae). Journal of Economic Entomology. 108(4): 2015–2020.
● 联系方式：
E-mail: guanfang@zzu.edu.cn
